Amino acids & related
5-HTP
Names you may see: 5 HTP 5 hydroxytryptophan L-5-HTP Griffonia simplicifolia
The quick take
5-HTP is a compound the body uses to make serotonin, a chemical involved in mood and sleep.
A closer look
What forms will I see on a label?
Labels may list 5-hydroxytryptophan or Griffonia seed extract. Check the amount of 5-HTP, rather than the total plant-extract weight.
Why people use it
People choose it for mood, relaxation, sleep and appetite-control goals.
These are common goals and marketing uses. The evidence section below explains what research supports.
What does the evidence tell us?
Small studies suggest possible benefits for some mood-related conditions, but the evidence is limited. It is not an established treatment for depression or insomnia.
What should I know before using it?
Do not combine it with antidepressants or other serotonin-raising medicines or supplements without medical guidance; serotonin syndrome can be serious. Nausea and digestive upset can occur. Discuss persistent mood or sleep symptoms with a clinician.
Sources & further reading
Content reviewed: September 30, 2026
General educational information. Follow the product label and seek individual advice when needed.