Amino acids & related
Agmatine
Names you may see: agmatine sulfate sulphate decarboxylated arginine
The quick take
Agmatine is made from arginine and appears in some pre-workout formulas.
A closer look
What forms will I see on a label?
Agmatine sulfate is the form commonly used in supplements. It is a different ingredient from L-arginine.
Why people use it
Pre-workout users seek muscle pumps, blood-flow support and training performance.
These are common goals and marketing uses. The evidence section below explains what research supports.
What does the evidence tell us?
Human evidence for improved pumps, muscle growth or strength is lacking. Small studies of nerve-related pain do not establish benefits for bodybuilding.
What should I know before using it?
Nausea and diarrhea have been reported. Long-term safety and medicine interactions are not well established; seek individual advice if you take medication or have a medical condition.
Sources & further reading
ISSN — exercise and sports nutrition review ↗
Published agmatine clinical trial ↗
Content reviewed: September 30, 2026
General educational information. Follow the product label and seek individual advice when needed.