Herbs & botanicals
Berberine
Names you may see: berberine HCl hydrochloride barberry metabolic
The quick take
Berberine is a compound found in several plants and used in metabolic-health supplements.
A closer look
What forms will I see on a label?
Labels may list berberine hydrochloride or a plant extract. Compare the actual berberine amount rather than assuming the extract weight is equivalent.
Why people use it
Marketed for blood-sugar, cholesterol and weight-management goals. Online comparisons with prescription weight-loss medicines overstate what is established.
These are common goals and marketing uses. The evidence section below explains what research supports.
What does the evidence tell us?
Some studies suggest metabolic effects, but weight-loss evidence remains inconclusive and study quality varies. It is not a substitute for prescribed diabetes or weight-management treatment.
What should I know before using it?
Berberine can interact with medicines and cause digestive upset. Avoid during pregnancy or breastfeeding and do not give it to infants. Discuss use with a clinician, particularly with glucose-lowering medicines.
Sources & further reading
NIH National Center for Complementary and Integrative Health ↗
Content reviewed: September 30, 2026
General educational information. Follow the product label and seek individual advice when needed.