Amino acids & related
Citrulline Malate
Names you may see: L-citrulline malic acid citrulline malate 2:1
The quick take
Citrulline malate combines citrulline with malate. Citrulline can increase arginine availability and is commonly used in pre-workout formulas.
A closer look
What forms will I see on a label?
A stated 2:1 ratio describes the blend. The total blend weight is not the same as the amount of pure L-citrulline.
Why people use it
Marketed for workout pumps, blood flow and reduced fatigue during demanding training sessions.
These are common goals and marketing uses. The evidence section below explains what research supports.
What does the evidence tell us?
Exercise studies have mixed results. Research does not establish that every citrulline-to-malate ratio produces superior performance.
What should I know before using it?
Digestive upset can occur. Discuss use with a pharmacist if you take blood-pressure or other cardiovascular medicines.
Sources & further reading
NIH Office of Dietary Supplements ↗
Content reviewed: September 30, 2026
General educational information. Follow the product label and seek individual advice when needed.