SD Pharmaceuticals Citrulline Malate 2000

Boost NO Production to Increase Blood Flow and Nutrient Delivery to Working Muscles

• Improves Energy and Endurance
• Reduces Fatigue and Muscle Soreness
• Increases Nitric Oxide for Better Pumps and Nutrient Delivery

WHAT IS IT?
Citrulline is an amino acid that is converted to L-arginine in the body during the urea cycle, alongside the other amino acid L-ornithine. Supplementing with citrulline is a more effective way to raise arginine levels and enhance NO production in the body than supplementing with arginine.

WHY IT’S BETTER
SD Pharmaceuticals’ CITRULLINE MALATE 2000 is formulated with a scientifically validated dose of pure citrulline malate. Citrulline has been shown in research to play a key role in aerobic and anaerobic pathways of energy metabolism, as well as nitric oxide (NO) production, demonstrating its ability to enhance energy, reduce fatigue and pump muscles up during workouts!

SD Pharmaceuticals’ CITRULLINE MALATE 2000 also delivers the supportive ingredient vitamin C and an absorption support complex.

HOW IT WORKS
In the body, citrulline is converted to L-arginine in the kidneys, increasing the level of L-arginine in blood plasma. L-arginine is then readily available to feed into the nitric oxide synthase (NOS) pathway of NO production, converting L-arginine into NO, increasing blood flow and nutrient delivery to working muscles. Citrulline also plays a role in ATP production, increasing energy demands when required while also buffering buildup of ammonia in the muscle, reducing exercise fatigue and increasing  workout endurance.

INCREASES ENERGY AND ENDURANCE
Citrulline can modulate enzymes involved in glycogen breakdown, glycogenolysis and enzymes that convert glucose to ATP through glycolysis. This action shifts muscle from aerobic to anaerobic metabolism, reducing the rate at which the body uses up ATP and phosphocreatine, while also accelerating their replenishment. This means more energy is available to the muscles for longer working sets, a reduction in muscle fatigue and longer cardio sessions!

REDUCES AMMONIA AND PREVENTS MUSCLE BURNOUT
Ammonia acts as a signal for muscle fatigue when it accumulates by inhibiting conversion of pyruvate to acetyl-CoA, blocking muscle contraction. Citrulline buffers ammonia via the urea cycle, increasing ornithine levels and promoting ureogenesis (production of urea) and bicarbonate reabsorption, which preserves bicarbonate and allows it to perform its buffering action against ammonia.

REDUCES POST-WORKOUT MUSCLE SORENESS
Citrulline malate supplementation has been shown to reduce post-workout muscle soreness for up to 48 hours in trained athletes, while also reducing the sensation and onset of muscle fatigue.

INCREASES NITRIC OXIDE (NO) PRODUCTION
Citrulline increases plasma levels of L-arginine in a dose-dependent manner. It has been shown that supplementing with citrulline malate helps increase the levels of L-arginine, which in turn allows for more availability of L-arginine for the NOS pathway of NO production. More NO means greater blood flow and better nutrient delivery to
working muscles.

RESTORES PROTEIN SYNTHESIS
Citrulline helps restore muscle protein synthesis rates and muscular function simply by improving nitrogen balance and encouraging use of amino acids—
particularly BCAA in muscles during exercise. Improved nitrogen retention and presence of BCAA helps signal the mTOR pathway of protein synthesis.

SUPPORTS NOS PRODUCTION – VITAMIN C
This antioxidant helps increase the activity of nitric oxide synthase (NOS), the enzyme that produces nitric oxide. It also helps sustain NO bioavailability.